ASHINGTON, Sept. 25 —
A parade of frustrated scientists told a Senate subcommittee
today that research on human embryonic stem cells was moving
exceedingly slowly because of the severe restrictions that
President Bush has imposed on federal financing for the
work.
"The field of human embryonic stem cell research is in a
fragile state at best under the current presidential policy,"
said Dr. George Q. Daley of the Whitehead Institute in Boston,
adding that the policy "threatens to starve the field at a
time when greater nourishment is critical."
Dr. Daley, who has used stem cells to cure mice of the
immune deficiency known as "bubble boy disease," was one of
several scientists who recounted the tribulations of trying to
obtain the cells Mr. Bush promised them in August 2001.
Scientists contend that embryonic stem cells, which can
form any of the body's cell types, will one day be used to
treat many diseases. But researchers must destroy human
embryos to get the cells, and that is why Mr. Bush restricted
federal financing to just the cell colonies that had been
identified at the time of his announcement.
The National Institutes of Health says there are 78
self-sustaining cell colonies, called lines, that researchers
may work on. The new director of the institutes, Dr. Elias
Zerhouni, told lawmakers today that he had set up a task force
to help get those lines into the hands of researchers.
But the scientists, while praising Dr. Zerhouni, said that
despite his efforts the vast majority of the lines were not
currently available. That is partly because some of the cells
are not fully developed and partly because researchers must go
through painstaking negotiations to persuade the companies and
universities that own the lines to share them.
Dr. Curt Civin, a stem cell researcher at Johns Hopkins
University, said he had spent months negotiating with an
Indian company that owns seven approved lines only to have his
agreement canceled in May when the Indian government put a
hold on all stem cell shipments.
Dr. Civin then paid $5,000 — 50 to 100 times the fee for
ordinary cells, he said — for a line from the University of
Wisconsin. But "technical problems" with the cells have kept
him from receiving them, he said. Dr. Civin has received some
private money for his work, but the foundation that gave him
the grant, following the federal lead, has insisted that he
use only the lines approved by the N.I.H.
"Embryonic stem cell research is crawling like a
caterpillar," Dr. Civin told the committee. The cells, he
said, are available "only to those persistent and patient
enough to jump through a series of hoops and endure lengthy
waits."
The tales of researchers' experiences prompted Senator
Arlen Specter, the Pennsylvania Republican who is chairman of
the hearing, to say later that he would press Congress to
expand the president's policy.
"I think the time has come," Mr. Specter said, "to
legislate in the field."
Whether Mr. Specter has the political support to do that is
unclear. Legislation to authorize so-called therapeutic
cloning, a type of stem cell research that also involves the
destruction of embryos, is stalled in the Senate, and Mr.
Specter acknowledged today that he would need to talk to his
colleagues before proposing another bill.
At least one state, California, is trying to encourage the
research. Over the weekend, Gov. Gray Davis signed a bill
explicitly authorizing human embryonic stem cell research. The
bill, which requires the studies to be regulated, is mostly
symbolic because it does not override the president's policy
on federal financing and does not set aside any new money for
the research.
Several researchers argued today that the National
Institutes of Health should set up a repository of stem cells
that all scientists could draw on. One researcher, Dr. Gerald
Schatten of the University of Pittsburgh, said he feared that
without enthusiastic support from the federal government, work
would proceed so slowly that the public would grow frustrated
and taxpayer support would dry up.
"If we're going to do this, let's do it," Dr. Schatten
said. "We didn't go to the moon and decide to come back
one-third of the way."