Top 10 Nanotechnology Companies

July 15, 2002

Larta picks ten nanotechnology companies that are poised to make a difference.


NanoSys
Founded by CEO Larry Bock, one of the biggest heavyweights in the small tech world, and who has funded and launched other successful biotech startups, Nanosys is Boston-based company that develops nanotechnology-enabled systems, with applications in molecular sensing, optoelectronics, and nanoelectronics. Bock's track record of launching over a dozen life science companies, and its IP, has helped Nanosys attract VC capital during one of the toughest eras for financing--last February the company announced $15 million in Series B financing from five top-tier firms. The company is relucant to disclose what it considers to be its smoking gun to enter the market, but has made considerable progress in nanometer transistors, which will thus enable a new generation of computer chips.


Hybrid Plastics
A U.S. Air Force Research Laboratory spin-off, Hybrid Plastics made its mark in the industry for the development of a revolutionary plastics technology derived from sand which is extremely strong, efficient, and does not cause air pollution during production. 205 companies buy trademarked nanostructured chemicals from the now privately held company, which is a recipient of the 2000 CalTIP award. Hybrid Plastics, which was able to grow in its early stages through the assistance of government R&D funding, now sell materials for research and development. The company's products are utilized for a variety of clients--optical, computing and electronics, and beauty corporations.

Chemat Technology
Considered survivors of government-funded research and development, Chemat became a profitable business in 2000 (half of that attributed to customer sales), a decade since the sol-gel solution company was founded. Prior to that, Chemat's R&D Division was successful in completing nearly one hundred contracts for government agencies and industry clients. Its mission is the creation and commercialization of sol-gel based advanced materials and technologies, for its own use and to provide its clients with technologies they can use to create leading-edge products using advanced materials.

Luxtera
A Caltech-UCLA spinoff, Luxtera was founded by two leaders in the field of nano photonics--Eli Yablonovitch, the inventor of the photonic crystal, and Dr. Axel Scherer, who has led pioneering work in nanoscale fabrication. Receiving $7 million in an A round last February, Luxtera's product is based on Caltech developments in the field of nanophotonics. This technology
is based upon optical structures which are an order of magnitude smaller than those traditionally used in integrated optical devices.
This technology could thus reduce the cost of optical-electronic transitions and optoelectronic systems.

Broadley-James
Broadley-James has the kind of business dilemma that most companies would gladly take on--supplying a heavy demand for its product. Thanks to a distribution decision made by Beckman Instruments back in the late 1960's, the company was able to penetrate the pH sensor market and become a leading manufacturer over the next three decades. It has positioned itself favorably by entering the biotech-pharmaceutical market, an industry that has increased production drastically (and thus created strong market demand). In order to reach its next stepping stone, Broadley-James was awarded a Larta-facilitated CalTIP grant last year, and will use those funds, as well as SBIR and UC grant support, to work towards improving and creating a new generation of pH sensors. The funds, still being budgeted for the project, will go towards marketing and promotion, as well as production engineering.

Nano Devices
In 2001, Nanodevices was one of the Santa Barbara companies Larta awarded CalTIP funding. This helped the company to complete a 2002 launch date, and NanoDevices is now shipping its Active Probe™ technology on the Digital Instruments, Veeco Metrology NanoScope® IV. In a move calculated to increase the growth of nanotube research, NanoDevices unveiled their EasyTube™ NanoFurnace in November 2001 at the Foresight Conference for Nanotechnology in Santa Clara. Designed to give researchers the ability to quickly and easily produce both single-wall carbon nanotubes (SWNT) and multi-wall carbon nanotubes (MWNT), the instrument is fully programmable and can be operational on the day of installation.

Insert Therapeutics
Another Caltech spinoff, Insert Therapeutics produces a non-viral, non-toxic, intracellular delivery system for small molecule drugs and genes. The company's work is based on research done in the laboratory of Mark Davis, a chemical engineering professor at Caltech. Unlike competing methodologies which simply "patch" new components onto established materials, the company's proprietary technology--CycloSert-- facilitates the efficient uptake and release of a range of drugs and genes directly into cells. This delivery technology can carry therapeutics of any size, ranging from drugs to DNA, and their combinations. This specifically addresses this delivery issue with DNA-based therapeutics, since site-directed, intracellular delivery is a critical obstacle to their successful clinical application.

Rockwell Scientific
Rockwell Scientific is one of the most prominent research and development labs focused on a wide array of innovative technologies, and has managed to developed a portfolio of technology and intellectual property that can be applied to several fields. However, several of its dollars have been flowing towards has nanotech-related research and development, most recently in the area of nano materials, fabrication, and nano magnetic particles, which it believes to have near term market potential.

Cyrano Sciences
The technological engine behind Cyrano is a proprietary sensing technology, also developed at Caltech. Cyrano is exploiting the value that is unleashed by the capability to digitize, archive, and analyze smell and provide low cost chemical information. Cyrano's product is a sensor array technology that provides a breakthrough capability to transform scents into digital "smellprints" via a small, low cost NoseChip (TM). Cyrano has established software protocols for converting data from these "smellprints" into actionable information for customers. Some of the applications for this technology include chemical weapon detection, food quality control, and disease detection.

Genefluidics
Founded two years ago from leading scientists and researchers at UCLA, Genefludics is a bio-focused nanotech company that is developing cutting-edge devices to revolutionize molecular analysis. The products are a bench-top analytical reader for multifunctional applications, and a hand-held reader for field use or point-of-care, able to detect and analyze DNA/RNA, as well as proteins and small molecules from raw samples. These devices produce highly accurate quantitative and qualitative results in minutes rather than hours or days, and drastically reduce the cost of assays to a fraction of the price needed by competing systems. The increased functionality and capabilities of the disposable unit will be targeted for applications in pharmaceutical and life sciences research.


The Nano Republic Conference 2002 - July 17
The Nano Republic Conference is a one-day Larta event featuring world-class speakers and highlighting California-wide Nanotechnology efforts. The Nano Republic Conference will serve as a serious examination of the current state of nanotechnology and focus on its near-term developments and constraints. The Nano Republic Conference will bring together all current industry segments and leaders from industry, academia, labs and the capital markets. Registration for the Nano Republic Conference will give you free admission to the ZONE Club dinner reception and program.
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The ZONE Club - July 17
Immediately following the Nano Republic Conference the ZONE Club will host a dinner/networking event featuring one of the leaders of the venture capital community. Steve Jurvetson, Managing Director, Draper Fisher Jurvetson, will speak on "Nanotechnology: What's Hot, What's Hype, What's Not"
6-7 Networking, cocktails and great food
7-8 Program
8-9 More networking, food and drink
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